Shark Liver Oil is a valuable remedy to fight chronic inflammation in the body. It supports cognitive function, and increases memory. It also builds the immune system.

Ingredients

Highly Purified Omega-3 Marine Oil, Highly Purified Deep Ocean Shark Liver Oil, Natural Lemon Flavor, Proprietory Antioxidant blend (consisting of rosemary extract, ascorbal palmitate, natural tocopherols).

Supplement Facts
Serving size 1 tsp (5 mL) Servings per container 40
Each teasponful contains ....% Daily Value

Calories (energy) 40
Calories from Fat 40
Total Fat 4g ...6%*
Staturated Fat 1g ...5%*
Polyunstaturated Fat 2g ...+
Cholesterol 15g ...5%
Shark Liver Oil proprietory blend 4544mg ...+
Omega-3 Fatty Acids ....... 1000mg ...+
EPA (Ecosapentaenoic acid). 525mg ...+
DHA (Docosahexaenoic acid). 325mg ...+
Other Omege-3 Fatty Acids . 150mg ...+
Alkylglycerols ............ 300mg ...+ from 750mg of diaclglycerol Ethers Squalene .................. 300mg ...+

*Percent Daily Value is based on a 2000 calorie diet

+ Daily Value not established

Instructions

Serving size: 1 tsp (5 mL). Servings per container: 40.

References and Research Info

If you would like to listen to or download free the radio broadcast interview about Shark Liver Oil visit our audio page and scroll to: Shark Liver Oil.

There is general scientific and medical agreement that uncontrolled inflammation in the body is the scourge of our time. DHA and EPA omega-3s support your natural defense mechanism. In proper quantities they help to quickly and naturally lower the inflammation in your body.

AKGs help to support and nourish your immune system. This 'TransFactor' process provides you with same precious immune-supporting AKGs that infants receive when nursing from their mothers.

J Altern Complement Med. 1998 Spring;4(1):87-99. Related Articles, Links

Some biological actions of alkylglycerols from shark liver oil.

Pugliese PT, Jordan K, Cederberg H, Brohult J.
Karolinska Institute (Soderjukhuset), Stockholm, Sweden.

Shark liver oil has been used for over 40 years as both a therapeutic and preventive agent. The active ingredients in shark liver oil have been found to be a group of ether-linked glycerols known as alkylglycerols. Initial clinical use was for treating leukemias, and later to prevent radiation sickness from cancer x-ray therapy. Studies over the last 30 years have shown that alkylglycerols are multifunctional. The level of natural alkylglycerols rises within tumor cells, apparently in an effort to control cell growth. Recent studies indicate that the activation of protein kinase C, an essential step in cell proliferation, can be inhibited by alkylglycerols. This action suggests a competitive inhibition of 1.2-diacylglycerol by alkylglycerols. Further studies on the immunostimulatory action of alkylglycerols suggest a primary action on the macrophage. The process of macrophage activation has been demonstrated with both synthetic and natural alkylglycerols. While the exact mechanism has not been found, both an autocrine and paracrine system have been suggested. Shark liver is a major natural source of alkylglycerols, which have no known side effects in dosages of 100 mg three times a day. The information presented in this article suggests that alkylglycerols may be used both as an adjunct therapy in the treatment of neoplastic disorders and as an immune booster in infectious diseases.

Natural Alkylglycerols Restrain Growth and Metastasis of Grafted Tumors in Mice

Alkylglycerols are natural etherlipids abundant in shark liver oil (SLO) in a diacylated form. SLO is known to have antitumor properties and was recently described as an inhibitor of tumor neovascularization. However, most studies did not discriminate between the respective activities of alkylglycerols and of fatty acids, which both have potent biological properties. In this work, a mouse model was used to investigate the antitumor effects of SLO and of alkylglycerols purified from the same source, both administered orally. We demonstrated that either pure alkylglycerols or SLO reduced the tumor growth in a similar manner, suggesting that alkylglycerols were involved in this effect. In alkylglycerol-treated mice, metastasis dissemination was reduced by 64 ± 8%, whereas SLO effect was 30 ± 9% below control. Purified alkylglycerols also decreased significantly plasmalogen content in tumors, whereas SLO had no such effect. Finally, we demonstrated that a 5-day treatment with alkylglycerols curtailed the presence in tumors of von Willebrand factor, a marker of endothelial cells. This result suggested an anti-angiogenic effect of alkylglycerols. In summary, alkylglycerols were shown to decrease the growth, vascularization, and dissemination of Lewis lung carcinoma tumors in mice. These findings suggest that the antitumor activity of SLO is likely mediated by the presence of alkylglycerols.

Frederique Pedrono, ​‌Benedicte Martin, ​‌Christine Leduc, ​‌Jacky Le Lan, ​‌Bernard Saiag, ​‌Philippe Legrand, ​‌Jacques-Philippe Moulinoux, ​‌Alain B. Legrand​‌

Omega-3 fatty acids in health and disease and in growth and development

AP Simopoulos
Center for Genetics, Nutrition and Health, Washington, DC 20009.

Several sources of information suggest that man evolved on a diet with a ratio of omega 6 to omega 3 fatty acids of approximately 1 whereas today this ratio is approximately 10:1 to 20-25:1, indicating that Western diets are deficient in omega 3 fatty acids compared with the diet on which humans evolved and their genetic patterns were established. Omega-3 fatty acids increase bleeding time; decrease platelet aggregation, blood viscosity, and fibrinogen; and increase erythrocyte deformability, thus decreasing the tendency to thrombus formation. In no clinical trial, including coronary artery graft surgery, has there been any evidence of increased blood loss due to ingestion of omega 3 fatty acids. Many studies show that the effects of omega 3 fatty acids on serum lipids depend on the type of patient and whether the amount of saturated fatty acids in the diet is held constant. In patients with hyperlipidemia, omega 3 fatty acids decrease low-density-lipoprotein (LDL) cholesterol if the saturated fatty acid content is decreased, otherwise there is a slight increase, but at high doses (32 g) they lower LDL cholesterol; furthermore, they consistently lower serum triglycerides in normal subjects and in patients with hypertriglyceridemia whereas the effect on high-density lipoprotein (HDL) varies from no effect to slight increases. The discrepancies between animal and human studies most likely are due to differences between animal and human metabolism. In clinical trials eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in the form of fish oils along with antirheumatic drugs improve joint pain in patients with rheumatoid arthritis; have a beneficial effect in patients with ulcerative colitis; and in combination with drugs, improve the skin lesions, lower the hyperlipidemia from etretinates, and decrease the toxicity of cyclosporin in patients with psoriasis. In various animal models omega 3 fatty acids decrease the number and size of tumors and increase the time elapsed before appearance of tumors. Studies with nonhuman primates and human newborns indicate that DHA is essential for the normal functional development of the retina and brain, particularly in premature infants. Because omega 3 fatty acids are essential in growth and development throughout the life cycle, they should be included in the diets of all humans. Omega-3 and omega 6 fatty acids are not interconvertible in the human body and are important components of practically all cell membranes. Whereas cellular proteins are genetically determined, the polyunsaturated fatty acid (PUFA) composition of cell membranes is to a great extent dependent on the dietary intake.